Coumadin Injection and Procarbazine Hydrochloride
Determining the interaction of Coumadin Injection and Procarbazine Hydrochloride and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:A case report describes a 62-year-old man treated with warfarin whose prothrombin times increased by 50% to 100% during three cycles of a chemotherapeutic regimen consisting of cyclophosphamide, doxorubicin, etoposide, mechlorethamine, vincristine, procarbazine, methotrexate, and prednisone. He developed a subconjunctival hemorrhage on day 1 of the first cycle. The prothrombin time returned to normal within one week of discontinuation of warfarin. Due to the complexity of the chemotherapeutic regimen, a causal relationship to any of the medications or combination of medications cannot be established.
- Seifter EJ, Brooks BJ, Urba WJ "Possible interactions between warfarin and antineoplastic drugs." Cancer Treat Rep 69 (1985): 244-5
Generic Name: warfarin
Brand name: Coumadin, Jantoven
Synonyms: Coumadin
Generic Name: procarbazine
Brand name: Matulane
Synonyms: Procarbazine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Coumadin Injection-Procardia
- Coumadin Injection-Procardia XL
- Coumadin Injection-ProCentra
- Coumadin Injection-Prochieve
- Coumadin Injection-Prochieve (Progesterone Vaginal 4% Gel)
- Coumadin Injection-Prochieve (Progesterone Vaginal 8% Gel)
- Procarbazine Hydrochloride-Covaryx
- Procarbazine Hydrochloride-Covaryx HS
- Procarbazine Hydrochloride-Covera-HS
- Procarbazine Hydrochloride-Cozaar
- Procarbazine Hydrochloride-CPB WC
- Procarbazine Hydrochloride-CPM-PSE DM Drops