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Coumadin Injection and Temsirolimus Intravenous

Determining the interaction of Coumadin Injection and Temsirolimus Intravenous and the possibility of their joint administration.

Check result:
Coumadin Injection <> Temsirolimus Intravenous
Relevance: 09.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using temsirolimus together with warfarin may increase the risk of bleeding in the brain. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR CLOSELY: According to the package labeling, patients receiving temsirolimus in combination with anticoagulation therapy may be at increased risk of developing intracerebral bleeding, including fatal outcomes. The mechanism of interaction has not been described.

MANAGEMENT: Patients receiving anticoagulants should be informed of the increased risk of developing intracerebral bleeding while on temsirolimus.

References
  • "Product Information. Torisel (temsirolimus)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
Coumadin Injection

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: Coumadin

Temsirolimus Intravenous

Generic Name: temsirolimus

Brand name: Torisel

Synonyms: Temsirolimus

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle