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Coumadin Injection and Testolactone

Determining the interaction of Coumadin Injection and Testolactone and the possibility of their joint administration.

Check result:

Coumadin Injection <> Testolactone

Relevance: 09.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using warfarin together with testolactone can cause you to bleed more easily. You may need a dose adjustment in addition to testing of your prothrombin time or International Normalized Ratio (INR). Call your doctor promptly if you have any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: According to the product labeling, testolactone may potentiate the hypoprothrombinemic effects of oral anticoagulants. The mechanism has not been described. The interaction has been reported with various androgens and anabolic steroids including danazol, oxymetholone, testosterone, methyltestosterone and stanozolol, resulting in bleeding complications and anticoagulant dosage reductions. However, it has not been reported with testolactone, a weak androgen and an aromatase inhibitor that is structurally distinct from true androgens.

MANAGEMENT: During concomitant therapy, the INR and/or PT should be monitored frequently and anticoagulant dosage adjusted accordingly, particularly following initiation or discontinuation of testolactone in patients who are stabilized on their anticoagulation regimen. Patients should be advised to promptly report any signs of bleeding to their physician, including pain, swelling, headache, dizziness, weakness, prolonged bleeding from cuts, increased menstrual flow, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools.

References

Wells PS, Holbrook AM, Crowther NR, Hirsh J "Interactions of warfarin with drugs and food." Ann Intern Med 121 (1994): 676-83
Edwards MS, Curtis JR "Decreased anticoagulant tolerance with oxymetholone." Lancet 2 (1971): 221
Goulbourne IA, Macleod DA "An interaction between danazol and warfarin: case report." Br J Obstet Gynaecol 88 (1981): 950-1
Murakami M, Odake K, Matsuda T, Onchi K, Umeda T, Nishino T "Effects of anabolic steroids on anticoagulant requirements." Jpn Circ J 29 (1965): 243-50
Longridge RG, Gillam PM, Barton GM "Decreased anticoagulant tolerance with oxymetholone." Lancet 2 (1971): 90
Husted S, Andreasen F, Foged L "Increased sensitivity to phenprocoumon during methyltestosterone therapy." Eur J Clin Pharmacol 10 (1976): 209-16
Small M, Peterkin M, Lower GD, et al "Danazol and oral anticoagulants." Scott Med J 27 (1982): 331-2
Pyorala K, Kekki M "Anabolic steroids and anticoagulant requirements." Lancet 2 (1963): 360-1
Shaw PW, Smith AM "Possible interaction of warfarin and stanozolol." Clin Pharm 6 (1987): 500-2
Lorentz SM, Weibert RT "Potentiation of warfarin anticoagulation by topical testosterone ointment." Clin Pharm 4 (1985): 333-5
Ekert H, Muntz RH, Colebatch JH "Decreased anticoagulant tolerance with oxymetholone." Lancet 2 (1971): 609-10
de Oya JC, del Rio A, Noya M, Villanueva A "Decreased anticoagulant tolerance with oxymetholone in paroxysmal nocturnal haemoglobinuria." Lancet 2 (1971): 259
Meeks ML, Mahaffey KW, Katz MD "Danazol increases the anticoagulant effect of warfarin." Ann Pharmacother 26 (1992): 641-2
Robinson BH, Hawkins JB, Ellis JE, Moore-Robinson M "Decreased anticoagulant tolerance with oxymetholone." Lancet 1 (1971): 1356
Schrogie JJ, Solomon HM "The anticoagulant response to bishydroxycoumarin. II. The effect of D-thyroxine, clofibrate, and norethandrolone." Clin Pharmacol Ther 8 (1967): 70-7
"Product Information. Teslac (testolactone)." Bristol-Myers Squibb, Princeton, NJ.

Coumadin Injection

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: Coumadin

What is Coumadin Injection?

Testolactone

Generic Name: testolactone

Brand name:

Synonyms: Testolactone (Oral)

What is Testolactone?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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