Coumadin Injection and Topamax (Topiramate Sprinkle Capsules)
Determining the interaction of Coumadin Injection and Topamax (Topiramate Sprinkle Capsules) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.MONITOR: Coadministration with topiramate may decrease the anticoagulant effects of vitamin K antagonists (VKAs). The mechanism has not been delineated. MANAGEMENT: Until more information is available, patients receiving VKAs with topiramate should be closely monitored during concomitant therapy. The prothrombin time (PT) or International Normalized Ratio (INR) should be checked frequently and the VKA dosage adjusted accordingly, particularly following initiation, change of dosage, or discontinuation of topiramate therapy. References Cerner Multum, Inc. "Australian Product Information." O 0 Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Professional:MONITOR: Coadministration with topiramate may decrease the anticoagulant effects of vitamin K antagonists (VKAs). The mechanism has not been delineated.
MANAGEMENT: Until more information is available, patients receiving VKAs with topiramate should be closely monitored during concomitant therapy. The prothrombin time (PT) or International Normalized Ratio (INR) should be checked frequently and the VKA dosage adjusted accordingly, particularly following initiation, change of dosage, or discontinuation of topiramate therapy.
- Cerner Multum, Inc. "Australian Product Information." O 0
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: warfarin
Brand name: Coumadin, Jantoven
Synonyms: Coumadin
Generic Name: topiramate
Brand name: Qudexy XR, Topamax, Topamax Sprinkle, Topiragen, Trokendi XR, Qudexy XR Sprinkle
Synonyms: Topamax
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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