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Coumadin Injection and Zinacef

Determining the interaction of Coumadin Injection and Zinacef and the possibility of their joint administration.

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Coumadin Injection <> Zinacef

Relevance: 09.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Cefuroxime may increase the effects of warfarin and cause you to bleed more easily. You may need more frequent monitoring of your INR after starting cefuroxime or whenever it is discontinued, and appropriate adjustments made in your dosage if necessary. Call your doctor immediately if you have any unusual bleeding, bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Cephalosporins may potentiate the anticoagulant effects of vitamin K antagonists. Possible mechanisms include inhibited growth of vitamin K-producing intestinal bacteria, inhibited production of vitamin K-dependent clotting factors via a methylthiotetrazole (MTT) side chain (e.g., cefamandole, cefmetazole, cefoperazone, cefotetan), and/or inhibited platelet activity. Decreased prothrombin activity has been reported during treatment with various cephalosporins. Risk factors include renal or hepatic impairment, poor nutritional state, protracted antimicrobial therapy, and chronic anticoagulation therapy.

MANAGEMENT: Prothrombin time and INR should be monitored and the patient closely observed for signs of bleeding. The anticoagulant dose may be adjusted as indicated. Patients should be advised to notify their physicians if they experience any signs or symptoms that may indicate excessive anticoagulation, such as unusual or prolonged bleeding, bruising, coffee ground emesis, change in stool or urine color, headache, dizziness, or weakness.

References

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Coumadin Injection

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: Coumadin

What is Coumadin Injection?

Zinacef

Generic Name: cefuroxime

Brand name: Zinacef, Ceftin, Kefurox, Zinacef ADD-Vantage, Zinacef TwistVial

Synonyms: n.a.

What is Zinacef?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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