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Covera-HS and Sulfinpyrazone

Determining the interaction of Covera-HS and Sulfinpyrazone and the possibility of their joint administration.

Check result:

Covera-HS <> Sulfinpyrazone

Relevance: 05.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Sulfinpyrazone may increase the clearance of verapamil. Serum verapamil levels and verapamil effects may be decreased. The mechanism and clinical significance are unknown. The effectiveness of verapamil during therapy should be monitored. Also, the clinician should be aware that verapamil effectiveness and risk of toxicity may increase when sulfinpyrazone is discontinued.

References

Wing LM, Miners JO, Lillywhite KJ "Verapamil disposition: effects of sulphinpyrazone and cimetidine." Br J Clin Pharmacol 19 (1985): 385-91

Covera-HS

Generic Name: verapamil

Brand name: Calan, Calan SR, Isoptin SR, Verelan, Isoptin, Isoptin IV, Covera-HS, Verelan PM

Synonyms: Covera-HS (Oral)

What is Covera-HS?

Sulfinpyrazone

Generic Name: sulfinpyrazone

Brand name:

Synonyms: Sulfinpyrazone (Oral)

What is Sulfinpyrazone?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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