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Creatine and Probenecid Tablets

Determining the interaction of Creatine and Probenecid Tablets and the possibility of their joint administration.

Check result:
Creatine <> Probenecid Tablets
Relevance: 03.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Cimetidine, trimethoprim, and probenecid are all known to interfere with the kidney's secretion of creatinine. Administration of creatine supplements to patients on these medications may lead to an increase in the serum level of these drugs and/or of creatinine. The physician should be aware that these increased serum levels may occur, and dosages may need to be adjusted or creatine supplementation may need to be discontinued as necessary.

References
  • Vandenberghe K, Gosris M, Van Hecke PV, Van Leemputte M, Vangerven L, Hespel P "Long-term creatine intake is beneficial to muscle performance during resistance training." J Appl Physiol 83 (1997): 2055-63
Creatine

Generic Name: creatine

Brand name: Cytotine

Synonyms: n.a.

Probenecid Tablets

Generic Name: probenecid

Brand name: Benemid

Synonyms: Probenecid

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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