Crixivan and Esomeprazole Strontium

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using indinavir together with esomeprazole. By reducing stomach acid, esomeprazole can decrease the absorption and blood levels of indinavir and make the medication less effective against HIV. Your doctor or pharmacist may be able to offer suggestions on safer alternatives if you require treatment for stomach acid or ulcer while you are being treated with indinavir. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Proton pump inhibitors may decrease the gastrointestinal absorption of indinavir. The proposed mechanism is a pH-dependent reduction in drug dissolution or absorption. The interaction has been reported specifically with omeprazole but may be expected with other proton pump inhibitors based on their common pharmacologic action.

MANAGEMENT: Caution is advised during the chronic use of these drugs with indinavir due to the risk of treatment failure and emergence of drug resistance associated with subtherapeutic levels of indinavir. Patients should be monitored for altered antiviral effectiveness.

Crixivan

Generic Name: indinavir

Brand name: Crixivan

Synonyms: n.a.

What is Crixivan?

Esomeprazole Strontium

Generic Name: esomeprazole

Brand name: Esomeprazole Strontium, Nexium, Nexium, NexIUM 24HR, Nexium IV

Synonyms: Esomeprazole

What is Esomeprazole Strontium?