Crixivan and Levothyroxine Oral Solution

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using levothyroxine together with indinavir may increase the effects of levothyroxine. Contact your doctor if you experience nervousness, palpitations, restlessness, weakness, and weight loss. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: A single case report suggests that indinavir may increase serum thyroxine concentrations, potentially resulting in hyperthyroidism. The proposed mechanism is indinavir inhibition of glucuronosyltransferase, which is partially responsible for the metabolic clearance of thyroxine. The case report describes an HIV-infected patient who had been stabilized on levothyroxine 0.75 mg/day for several years when treatment with stavudine, lamivudine, and indinavir was begun. Approximately 50 days later, she presented with nervousness, palpitations, restlessness, weakness, and slight weight loss. Thyroid function testing revealed suppression of thyroid-stimulating hormone (TSH less than 0.1 mIU/L), increased free T4 (57 pmol/L), and increased free T3 (33 pmol/L). Thyroid function returned to normal one month after the levothyroxine dose was reduced to 0.12 mg/day.

MANAGEMENT: During coadministration with indinavir, the possibility of an enhanced therapeutic response to levothyroxine should be considered. Dosage adjustment as well as clinical and laboratory monitoring may be appropriate whenever indinavir is added to or withdrawn from therapy.

Crixivan

Generic Name: indinavir

Brand name: Crixivan

Synonyms: n.a.

What is Crixivan?

Levothyroxine Oral Solution

Generic Name: levothyroxine

Brand name: Levoxyl, Synthroid, Tirosint, Unithroid, Euthyrox, Levothroid, Tirosint-Sol

Synonyms: Levothyroxine

What is Levothyroxine Oral Solution?