Crixivan and Mepron

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using atovaquone together with indinavir can decrease the effects of indinavir. Contact your doctor if your condition worsens. You may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration of atovaquone (750 mg twice a day with food) and indinavir (800 mg three times a day without food) for 14 days has been shown to decrease the trough plasma concentration (Cmin) of indinavir by 23%. The mechanism and clinical significance of this interaction are unknown. Steady-state indinavir peak plasma concentration (Cmax) and systemic exposure (AUC) were not altered by atovaquone.

MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiretroviral drug levels, caution is recommended in patients receiving indinavir in combination with atovaquone. Antiretroviral response should be closely monitored.

Crixivan

Generic Name: indinavir

Brand name: Crixivan

Synonyms: n.a.

What is Crixivan?

Mepron

Generic Name: atovaquone

Brand name: Mepron

Synonyms: n.a.

What is Mepron?