Crixivan and Retrovir oral/injection

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Indinavir has been shown to increase the area under the plasma concentration-time curves of the reverse transcriptase inhibitors zidovudine and stavudine by up to 36% and 25%, respectively. Concomitant use has inconsistently affected indinavir plasma concentrations, which have increased by up to 13% or have shown no change. The mechanism of the interaction is not clearly understood, but it may be related to the effects of these drugs on hepatic enzymes. Dosage adjustments are unlikely to be necessary, although it may be appropriate to monitor the patient for zidovudine and/or stavudine toxicity.

Crixivan

Generic Name: indinavir

Brand name: Crixivan

Synonyms: n.a.

What is Crixivan?

Retrovir oral/injection

Generic Name: zidovudine

Brand name: Retrovir

Synonyms: Retrovir (oral/injection), Retrovir

What is Retrovir oral/injection?