Crysvita and Fleet Enema rectal

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using burosumab together with sodium phosphate is not recommended. Combining these medications may cause excessive elevations in phosphorus and vitamin D levels in the blood, which may lead to increased risk of kidney stones. Over time, you may also have bone and muscle problems as well as increased risk of heart attacks and strokes if the blood levels remain high. Most products containing phosphates and greater than nutritional allowances of vitamin D should generally be discontinued for one week before starting treatment with burosumab. Talk to your doctor if you have any questions or concerns. During treatment, phosphorus blood levels should be closely monitored, which will allow your doctor to determine when a dose adjustment or an interruption in treatment may be required. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Concomitant use of burosumab with oral phosphate and/or active vitamin D analogs may increase the risk of hyperphosphatemia and hypervitaminosis D due to additive pharmacologic effects. Increases in serum phosphorus to above the upper limit of normal may be associated with an increased risk of nephrocalcinosis.

MANAGEMENT: Oral phosphate and active vitamin D analogs should be discontinued one week prior to initiation of burosumab treatment. Fasting serum phosphorus concentration should be below the reference range for age prior to initiation of treatment.

Crysvita

Generic Name: burosumab

Brand name: Crysvita

Synonyms: n.a.

What is Crysvita?

Fleet Enema rectal

Generic Name: sodium biphosphate / sodium phosphate

Brand name: Disposable Enema, Fleet Enema, OsmoPrep

Synonyms: Fleet Enema (rectal)

What is Fleet Enema rectal?