Cubicin RF and Doxapram Hydrochloride

• Generic Name: daptomycin
• Dosage Forms: injection, powder, lyophilized, for solution
• Other Brand Names: Cubicin, Cubicin RF

Cubicin RF is an antibiotic that is used to treat bacterial infections of the skin and underlying tissues, and infections that have entered the bloodstream.

Cubicin RF is used for complicated infections, including MRSA or "super bug" infections. MRSA stands for methicillin-resistant Staphylococcus aureus.

Cubicin RF may also be used for purposes not listed in this medication guide.

• Generic Name: doxapram
• Dosage Forms: n.a.
• Other Brand Names: Dopram

Treatment of drug-induced postanesthetic respiratory depression or apnea not caused by skeletal muscle relaxants.

Other supportive therapy preferred due to questionable benefit and high potential for toxicity with doxapram. Limited role due to availability of safer and shorter-acting anesthetic agents.

Has been used in conjunction with supportive measures to stimulate respiration and hasten arousal in patients with respiratory and CNS depression secondary to drug overdose (e.g., barbiturates, opiate analgesics, general anesthetics).

However, use as an analeptic is strongly discouraged by most clinicians; analeptic therapy largely abandoned in favor of intensive supportive care (e.g., mechanical ventilation, oxygenation, cardiovascular support) and specific antidotes (e.g., pure opiate antagonists).

Short-term use in patients with acute respiratory insufficiency associated with COPD.

Role in such patients is limited; other supportive therapy (i.e., noninvasive ventilation using either negative- or positive-pressure device) is preferred.

Has been used for the treatment of neonatal apnea, principally in combination with theophylline or caffeine.

Limited support for this use; no apparent advantage over methylxanthines and risk of substantial adverse effects with doxapram therapy. The commercially available injection contains benzyl alcohol; use of this preparation in neonates is not recommended. (See Pediatric Use under Cautions.)

Should not be used in conjunction with mechanical ventilation.