Cuprimine and Digoxin

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using penicillAMINE together with digoxin may decrease the effects of digoxin. Contact your doctor if your condition changes or if you experience worsening of your heart symptoms. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with penicillamine may decrease the serum concentrations of digoxin. In ten patients stabilized on digoxin therapy, administration of penicillamine (1 gram oral dose) two hours after the digoxin dose resulted in an approximately 40% decrease in serum digoxin levels measured at six hours postdose. When digoxin was administered intravenously, corresponding serum digoxin levels were reduced 65% by penicillamine. In ten children with congestive heart failure receiving digoxin 0.02 mg/kg/day for 6 days, the same dose of penicillamine decreased mean serum digoxin levels by 39%. The mechanism of interaction has not been established.

MANAGEMENT: Caution is advised if digoxin must be used with penicillamine. Pharmacologic response and serum digoxin levels should be monitored more closely whenever penicillamine is added to or withdrawn from therapy, and the digoxin dosage adjusted as necessary. Patients should be advised to notify their physician if they experience worsening of their heart symptoms during coadministration with penicillamine.

Cuprimine

Generic Name: penicillamine

Brand name: Cuprimine, Depen, D-Penamine, Depen Titratabs

Synonyms: n.a.

What is Cuprimine?

Digoxin

Generic Name: digoxin

Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin

Synonyms: n.a.

What is Digoxin?