Cuprimine and Zinc Gluconate Capsules and Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

PenicillAMINE and zinc gluconate should not be taken orally at the same time. Products that contain magnesium, aluminum, calcium, iron, and/or other minerals may interfere with the absorption of penicillAMINE and reduce its effectiveness. You should take zinc gluconate at least 2 hours before or 2 hours after the penicillAMINE dose. Contact your doctor if your condition worsens. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSING INTERVAL: Oral administration of aluminum, copper, iron, zinc, magnesium, and possibly other minerals such as calcium may decrease the gastrointestinal absorption of penicillamine, and vice versa. The proposed mechanism involves chelation of penicillamine to polyvalent cations, which leads to formation of a nonabsorbable complex. In a study of six healthy volunteers, administration of penicillamine (500 mg) following a single dose of ferrous sulfate (300 mg) or antacid (Maalox Plus 30 mL) reduced the mean peak plasma concentration of penicillamine by 65% and 34%, respectively, compared to administration in the fasting state. These changes could result in diminished therapeutic effects of penicillamine.

When used concomitantly with copper-chelating agents for the treatment of Wilson's disease, zinc salts can compete with copper for chelation and renal excretion. The clinical significance is unknown, although reduced efficacy of one or both agents may theoretically occur. Zinc alone can reduce copper levels by blocking its absorption in the intestine and promoting fecal copper excretion. A small study found that adding penicillamine (1 gm/day) or trientine (1 gm/day) to zinc therapy reduced fecal copper excretion but increased urinary excretion, with the overall copper balance not appreciably changed compared to during zinc therapy alone. In the study, the chelating agent and zinc were given one hour apart. It is not known if simultaneous administration would result in more clinically significant alterations. Other studies have reported on the effectiveness of combination therapy in some patients. However, no data are available to demonstrate that zinc should be added to other drugs used for the treatment of Wilson's disease.

MANAGEMENT: Mineral supplements or other products containing polyvalent cations should be administered at least two hours before or two hours after the penicillamine dose if possible.

Cuprimine

Generic Name: penicillamine

Brand name: Cuprimine, Depen, D-Penamine, Depen Titratabs

Synonyms: n.a.

What is Cuprimine?

Zinc Gluconate Capsules and Tablets

Generic Name: zinc gluconate

Brand name: Orazinc, Orazinc 110

Synonyms: Zinc gluconate, Zinc Gluconate

What is Zinc Gluconate Capsules and Tablets?