Cyclobenzaprine Extended-Release Capsules and Levoleucovorin Calcium

• Generic Name: cyclobenzaprine
• Dosage Forms: n.a.
• Other Brand Names: Amrix, Comfort Pac with Cyclobenzaprine, Fexmid, Flexeril

• It is used to relax muscles.

• Generic Name: levoleucovorin
• Dosage Forms: n.a.
• Other Brand Names: Fusilev, Khapzory

IV rescue therapy after high-dose methotrexate therapy (to control the duration of exposure of sensitive cells to methotrexate) for treatment of osteosarcoma (designated an orphan drug by FDA for this use).

Antidote to diminish the toxicity and counteract the effects of unintentional overdosage of methotrexate (e.g., resulting from impaired elimination) and other folic acid antagonists (designated an orphan drug by FDA for this use).

In combination with fluorouracil for the palliative treatment of advanced-stage colorectal cancer.

Has been studied for treatment of advanced-stage colorectal cancer in combination with fluorouracil and other agents (i.e., irinotecan, oxaliplatin). However, use in such combination regimens not fully established.

Manufacturer states that levoleucovorin should not be used for the treatment of pernicious anemia and megaloblastic anemias secondary to lack of vitamin B12; such use may alleviate hematologic manifestations while allowing neurologic complications to progress.