Cyclophosphamide and Levaquin (Levofloxacin Tablets)
Determining the interaction of Cyclophosphamide and Levaquin (Levofloxacin Tablets) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Limited data suggest that chemotherapy with antineoplastic agents may reduce the plasma concentrations of oral quinolone antibiotics. The proposed mechanism is decreased quinolone absorption secondary to alteration of intestinal mucosa by cancer chemotherapy. In six patients with newly diagnosed hematologic malignancy, treatment with various antineoplastic agents (cyclophosphamide, cytarabine, daunorubicin, doxorubicin, mitoxantrone, prednisolone, vincristine) decreased the mean peak serum concentration (Cmax) and area under the concentration-time curve (AUC 0 to 4 hours) of ciprofloxacin by approximately 46% each. Data are not available for other quinolone antibiotics.
- Johnson EJ, MacGowan AP, Potter MN, et al "Reduced absorption of oral ciprofloxacin after chemotherapy for haematological malignancy." J Antimicrob Chemother 25 (1990): 837-42
Generic Name: cyclophosphamide
Brand name: Cytoxan, Neosar, Cytoxan Lyophilized
Synonyms: Cyclophosphamide (oral and injection)
Generic Name: levofloxacin
Brand name: Levaquin
Synonyms: Levaquin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cyclophosphamide-Levaquin injection
- Cyclophosphamide-Levaquin Intravenous
- Cyclophosphamide-Levaquin Oral Solution
- Cyclophosphamide-Levatio Patch
- Cyclophosphamide-Levatol
- Cyclophosphamide-Levbid ER Tablets
- Levaquin (Levofloxacin Tablets)-Cyclophosphamide Capsules
- Levaquin (Levofloxacin Tablets)-Cyclophosphamide Injection
- Levaquin (Levofloxacin Tablets)-Cyclophosphamide oral and injection
- Levaquin (Levofloxacin Tablets)-Cyclophosphamide Oral, Intravenous
- Levaquin (Levofloxacin Tablets)-Cyclophosphamide Tablets
- Levaquin (Levofloxacin Tablets)-Cycloserine