Cyclophosphamide Capsules and Flagyl I.V. Intravenous
Determining the interaction of Cyclophosphamide Capsules and Flagyl I.V. Intravenous and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using cyclophosphamide together with metroNIDAZOLE may increase the effects of cyclophosphamide. This could cause encephalopathy (swelling of the brain) with hallucinations and seizures. Contact your doctor if your condition worsens. You may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: An isolated case of encephalopathy with hallucinations and seizures has been reported in a child during concomitant treatment with metronidazole and cyclophosphamide. The mechanism is unknown, but accumulation of toxic metabolites of cyclophosphamide may be involved.
MANAGEMENT: Monitoring for adverse CNS effects may be advisable during coadministration.
- Pinsk MN, Renton K, Crocker JFS, Acott PD "A proposed drug interaction leading to cyclophosphamide-induced encephalopathy." Pediatr Res 51 (2002): 437A
- Cerner Multum, Inc. "Australian Product Information." O 0
- "Multum Information Services, Inc. Expert Review Panel"
Generic Name: cyclophosphamide
Brand name: Cytoxan, Neosar, Cytoxan Lyophilized
Synonyms: Cyclophosphamide (oral and injection), Cyclophosphamide
Generic Name: metronidazole
Brand name: Flagyl, FIRST Metronidazole, Flagyl 375, MetroGel
Synonyms: Flagyl I.V. (Intravenous), Flagyl Injection
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cyclophosphamide Capsules-Flagyl I.V. RTU Intravenous
- Cyclophosphamide Capsules-Flagyl Injection
- Cyclophosphamide Capsules-Flagyl Oral, Intravenous
- Cyclophosphamide Capsules-Flagyl Vaginal
- Cyclophosphamide Capsules-Flamazine Topical
- Cyclophosphamide Capsules-Flanax
- Flagyl I.V. Intravenous-Cyclophosphamide Injection
- Flagyl I.V. Intravenous-Cyclophosphamide oral and injection
- Flagyl I.V. Intravenous-Cyclophosphamide Oral, Intravenous
- Flagyl I.V. Intravenous-Cyclophosphamide Tablets
- Flagyl I.V. Intravenous-Cycloserine
- Flagyl I.V. Intravenous-Cycloserine Capsules