Cyclophosphamide Capsules and Phenobarbital Elixir
Determining the interaction of Cyclophosphamide Capsules and Phenobarbital Elixir and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Phenobarbital may enhance the metabolism of cyclophosphamide (and its metabolites) by increasing the rate of biotransformation of cyclophosphamide to its active metabolites. The clinical significance of this interaction appears to be minimal.
- Garattini S, Spreafico F "Some examples of interactions between drugs in cancer chemotherapy." Antibiot Chemother 23 (1978): 283-94
- Jao JY, Jusko WJ, Cohen JL "Phenobarbital effects on cyclophosphamide pharmacokinetics in man." Cancer Res 32 (1972): 2761-4
Generic Name: cyclophosphamide
Brand name: Cytoxan, Neosar, Cytoxan Lyophilized
Synonyms: Cyclophosphamide (oral and injection), Cyclophosphamide
Generic Name: phenobarbital
Brand name: Solfoton, Luminal
Synonyms: Phenobarbital, PHENobarbital
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cyclophosphamide Capsules-Phenobarbital Injection
- Cyclophosphamide Capsules-Phenobarbital Oral Solution
- Cyclophosphamide Capsules-Phenobarbital Sodium
- Cyclophosphamide Capsules-Phenobarbital Sodium Injection
- Cyclophosphamide Capsules-Phenobarbital Tablets
- Cyclophosphamide Capsules-Phenobarbital with Belladonna Alkaloids Elixir
- Phenobarbital Elixir-Cyclophosphamide Injection
- Phenobarbital Elixir-Cyclophosphamide oral and injection
- Phenobarbital Elixir-Cyclophosphamide Oral, Intravenous
- Phenobarbital Elixir-Cyclophosphamide Tablets
- Phenobarbital Elixir-Cycloserine
- Phenobarbital Elixir-Cycloserine Capsules