Cyclophosphamide Capsules and Zofran ODT
Determining the interaction of Cyclophosphamide Capsules and Zofran ODT and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Limited data have shown that ondansetron may significantly decrease the area under the plasma concentration-time curve (AUC) for cyclophosphamide. Theoretically, this interaction could decrease the pharmacologic effect of cyclophosphamide, but, clinically, the significance of this interaction is not known. More data are needed.
- Gilbert CJ, Petros WP, Cavanaugh C, et al. "Influence of ondansetron (OND) on the pharmacokinetics (PK) of high dose cyclophosphamide (CPA) (Meeting abstract)." Proc Annu Meet Am Soc Clin Oncol 14 (1995): a9311995
Generic Name: cyclophosphamide
Brand name: Cytoxan, Neosar, Cytoxan Lyophilized
Synonyms: Cyclophosphamide (oral and injection), Cyclophosphamide
Generic Name: ondansetron
Brand name: Zofran, Zofran ODT, Zuplenz
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cyclophosphamide Capsules-Zofran ODT Oral, Oromucosal
- Cyclophosphamide Capsules-Zofran Oral, Oromucosal
- Cyclophosphamide Capsules-Zohydro ER
- Cyclophosphamide Capsules-Zohydro ER Capsules
- Cyclophosphamide Capsules-Zoladex
- Cyclophosphamide Capsules-Zoladex (Goserelin Implant 10.8 mg)
- Zofran ODT-Cyclophosphamide Injection
- Zofran ODT-Cyclophosphamide oral and injection
- Zofran ODT-Cyclophosphamide Oral, Intravenous
- Zofran ODT-Cyclophosphamide Tablets
- Zofran ODT-Cycloserine
- Zofran ODT-Cycloserine Capsules