Cyclophosphamide Injection and Zofran (Ondansetron Tablets)
Determining the interaction of Cyclophosphamide Injection and Zofran (Ondansetron Tablets) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Limited data have shown that ondansetron may significantly decrease the area under the plasma concentration-time curve (AUC) for cyclophosphamide. Theoretically, this interaction could decrease the pharmacologic effect of cyclophosphamide, but, clinically, the significance of this interaction is not known. More data are needed.
- Gilbert CJ, Petros WP, Cavanaugh C, et al. "Influence of ondansetron (OND) on the pharmacokinetics (PK) of high dose cyclophosphamide (CPA) (Meeting abstract)." Proc Annu Meet Am Soc Clin Oncol 14 (1995): a9311995
Generic Name: cyclophosphamide
Brand name: Cytoxan, Neosar, Cytoxan Lyophilized
Synonyms: Cyclophosphamide (oral and injection), Cyclophosphamide
Generic Name: ondansetron
Brand name: Zofran, Zofran ODT, Zuplenz
Synonyms: Zofran
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cyclophosphamide Injection-Zofran injection
- Cyclophosphamide Injection-Zofran ODT
- Cyclophosphamide Injection-Zofran ODT Oral, Oromucosal
- Cyclophosphamide Injection-Zofran Oral, Oromucosal
- Cyclophosphamide Injection-Zohydro ER
- Cyclophosphamide Injection-Zohydro ER Capsules
- Zofran (Ondansetron Tablets)-Cyclophosphamide oral and injection
- Zofran (Ondansetron Tablets)-Cyclophosphamide Oral, Intravenous
- Zofran (Ondansetron Tablets)-Cyclophosphamide Tablets
- Zofran (Ondansetron Tablets)-Cycloserine
- Zofran (Ondansetron Tablets)-Cycloserine Capsules
- Zofran (Ondansetron Tablets)-Cycloset