Cyclophosphamide oral and injection and Digoxin oral/injection
Determining the interaction of Cyclophosphamide oral and injection and Digoxin oral/injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Some cancer drugs like cyclophosphamide can cause damage to the intestinal lining and interfere with the absorption of digoxin. Blood levels and effects of digoxin may be reduced during chemotherapy. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition worsens or you experience increased symptoms of heart failure such as tiredness, swelling, fluid retention, sudden weight gain, difficulty breathing, shortness of breath, irregular heartbeat, or chest pain. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: The use of some antineoplastic agents has been associated with decreased gastrointestinal absorption of digoxin. The suspected mechanism is alteration of the gastrointestinal mucosa. The risk of an interaction is expected to be less with digoxin solution in capsules because absorption occurs rapidly in the upper GI tract.
MANAGEMENT: Digoxin serum levels and effectiveness should be monitored closely following the initiation or discontinuation of antineoplastic agents, and the dosage adjusted as necessary.
- Kuhlmann J, Zilly W, Wilke J "Effects of cytostatic drugs on plasma level and renal excretion of beta-acetyldigoxin." Clin Pharmacol Ther 30 (1981): 518-27
- Rodin SM, Johnson BF "Pharmacokinetic interactions with digoxin." Clin Pharmacokinet 15 (1988): 227-44
- Bjornsson TD, Huang AT, Roth P, Jacob DS, Christenson R "Effects of high-dose cancer chemotherapy on the absorption of digoxin in two different formulations." Clin Pharmacol Ther 39 (1986): 25-8
- Kuhlmann J, Wilke J, Rietbrock N "Cytostatic drugs are without significant effect on digitoxin plasma level and renal excretion." Clin Pharmacol Ther 32 (1982): 646-51
- "Product Information. Lanoxicaps (digoxin)." Glaxo Wellcome, Research Triangle Park, NC.
Generic Name: cyclophosphamide
Brand name: Cytoxan, Neosar, Cytoxan Lyophilized
Synonyms: Cyclophosphamide (oral and injection), Cyclophosphamide
Generic Name: digoxin
Brand name: Digitek, Digox, Lanoxin, Lanoxicaps, Cardoxin
Synonyms: Digoxin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cyclophosphamide oral and injection-Digoxin Tablets
- Cyclophosphamide oral and injection-Dihydro CP Syrup
- Cyclophosphamide oral and injection-Dihydrocodeine BPM Phenyleph HCl
- Cyclophosphamide oral and injection-Dihydrocodeine, Aspirin, and Caffeine
- Cyclophosphamide oral and injection-Dihydroergotamine
- Cyclophosphamide oral and injection-Dihydroergotamine injection
- Digoxin oral/injection-Cyclophosphamide Oral, Intravenous
- Digoxin oral/injection-Cyclophosphamide Tablets
- Digoxin oral/injection-Cycloserine
- Digoxin oral/injection-Cycloserine Capsules
- Digoxin oral/injection-Cycloset
- Digoxin oral/injection-Cyclosporine