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Cyclophosphamide Oral, Intravenous and Imuran

Determining the interaction of Cyclophosphamide Oral, Intravenous and Imuran and the possibility of their joint administration.

Check result:

Cyclophosphamide Oral, Intravenous <> Imuran

Relevance: 26.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using azaTHIOprine together with cyclophosphamide can cause serious side effects that may affect your liver. Call your doctor immediately if you experience a fever, chills, joint pain or swelling, excessive tiredness or weakness, unusual bleeding or bruising, skin rash or itching, loss of appetite, nausea, vomiting, or yellowing of the skin or the whites of your eyes. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Concomitant administration of azathioprine and cyclophosphamide may cause hepatotoxicity, in some cases associated with hepatocellular necrosis. The mechanism is unknown. In addition, the risk of bone marrow suppression may be increased when azathioprine and cyclophosphamide are coadministered.

MANAGEMENT: If concomitant therapy is needed patients should be monitored for signs and symptoms of hepatotoxicity and myelotoxicity. Patients should be advised to promptly notify their physician if they experience fever, chills, sore throat, mouth sores, unusual fatigue, bleeding, bruising, abdominal pain, darkened urine, or pale stools.

References

Shaunak S, Munro JM, Weinbren K, Walport MJ, Cox TM "Cyclophosphamide-induced liver necrosis: a possible interaction with azathioprine." Q J Med 67 (1988): 309-17

Cyclophosphamide Oral, Intravenous

Generic Name: cyclophosphamide

Brand name: Cytoxan, Neosar, Cytoxan Lyophilized

Synonyms: Cyclophosphamide (oral and injection), Cyclophosphamide

What is Cyclophosphamide Oral, Intravenous?

Imuran

Generic Name: azathioprine

Brand name: Azasan, Imuran

Synonyms: n.a.

What is Imuran?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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