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Cyclophosphamide Oral, Intravenous and Zofran (Ondansetron Oral Solution)

Determining the interaction of Cyclophosphamide Oral, Intravenous and Zofran (Ondansetron Oral Solution) and the possibility of their joint administration.

Check result:

Cyclophosphamide Oral, Intravenous <> Zofran (Ondansetron Oral Solution)

Relevance: 26.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Limited data have shown that ondansetron may significantly decrease the area under the plasma concentration-time curve (AUC) for cyclophosphamide. Theoretically, this interaction could decrease the pharmacologic effect of cyclophosphamide, but, clinically, the significance of this interaction is not known. More data are needed.

References

Gilbert CJ, Petros WP, Cavanaugh C, et al. "Influence of ondansetron (OND) on the pharmacokinetics (PK) of high dose cyclophosphamide (CPA) (Meeting abstract)." Proc Annu Meet Am Soc Clin Oncol 14 (1995): a9311995

Cyclophosphamide Oral, Intravenous

Generic Name: cyclophosphamide

Brand name: Cytoxan, Neosar, Cytoxan Lyophilized

Synonyms: Cyclophosphamide (oral and injection), Cyclophosphamide

What is Cyclophosphamide Oral, Intravenous?

Zofran (Ondansetron Oral Solution)

Generic Name: ondansetron

Brand name: Zofran, Zofran ODT, Zuplenz

Synonyms: Zofran

What is Zofran (Ondansetron Oral Solution)?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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