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Cyclosporine and Diamox

Determining the interaction of Cyclosporine and Diamox and the possibility of their joint administration.

Check result:

Cyclosporine <> Diamox

Relevance: 26.09.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using cycloSPORINE together with acetaZOLAMIDE may increase the effects of cycloSPORINE. Contact your doctor if you experience nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, or headache. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Carbonic anhydrase inhibitors (CAIs) may increase serum cyclosporine levels. The mechanism is unknown. Cyclosporine-induced neurotoxicity and nephrotoxicity could result.

MANAGEMENT: If cyclosporine and a CAI are used together, cyclosporine levels and renal function, including serum creatinine, should be carefully monitored. Cyclosporine dosage should be adjusted as needed. Patients should be advised to notify their physician if they experience nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, or headache.

References

Tabbara KF, AlFaisal Z, AlRashed W "Interaction between acetazolamide and cyclosporine." Arch Ophthalmol 116 (1998): 832-3
Keogh A, Esmore D, Spratt P, Savdie E, McCluskey P, Chang V "Acetazolamide and cyclosporine." Transplantation 46 (1988): 478-9

Cyclosporine

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Cyclosporine (oral/injection), CycloSPORINE (Systemic)

What is Cyclosporine?

Diamox

Generic Name: acetazolamide

Brand name: Diamox, Diamox Sequels

Synonyms: n.a.

What is Diamox?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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