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Cyclosporine and Plazomicin Intravenous

Determining the interaction of Cyclosporine and Plazomicin Intravenous and the possibility of their joint administration.

Check result:

Cyclosporine <> Plazomicin Intravenous

Relevance: 26.09.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using cycloSPORINE together with plazomicin may increase the risk of kidney damage. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Signs and symptoms of kidney damage may include nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Let your doctor know if you experience some or all of these problems during treatment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: The nephrotoxic effects of cyclosporine and aminoglycosides are additive. The combination generally should be avoided.

MANAGEMENT: If these agents must be used concomitantly, renal function should be closely monitored.

References

"Product Information. Arikayce (amikacin liposome)." Insmed Incorporated, Bridgewater, NJ.
Termeer A, Hoitsma AJ, Koene RA "Severe nephrotoxicity caused by the combined use of gentamicin and cyclosporine in renal allograft recipients." Transplantation 42 (1986): 220-1
Chandrasekar PH, Cronin SM "Nephrotoxicity in bone marrow transplant recipients receiving aminoglycoside plus cyclosporine or aminoglycoside alone." J Antimicrob Chemother 27 (1991): 845-9
Whiting PH, Simpson JG "The enhancement of cyclosporin A-induced nephrotoxicity by gentamicin." Biochem Pharmacol 32 (1983): 2025-8
"Product Information. Sandimmune (cyclosporine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
Cockburn IT, Krupp P "An appraisal of drug interactions with sandimmun." Transplant Proc 21 (1989): 3845-50

Cyclosporine

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Cyclosporine (oral/injection), CycloSPORINE (Systemic)

What is Cyclosporine?

Plazomicin Intravenous

Generic Name: plazomicin

Brand name: Zemdri

Synonyms: Plazomicin

What is Plazomicin Intravenous?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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