Cyclosporine Injection and Nexavar
Determining the interaction of Cyclosporine Injection and Nexavar and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:SORAfenib may increase the blood levels and effects of cycloSPORINE. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Based on in vitro inhibition data, coadministration with sorafenib may increase the plasma concentrations of drugs that are substrates of the P-glycoprotein (P-gp) transporter. The proposed mechanism is decreased clearance in the intestine, liver, and/or kidney due to inhibition of P-glycoprotein-mediated drug efflux by sorafenib.
MANAGEMENT: Caution is advised when sorafenib is used concurrently with drugs that are known P-gp substrates, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever sorafenib is added to or withdrawn from therapy.
- "Product Information. Nexavar (sorafenib)." Bayer Pharmaceutical Inc, West Haven, CT.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: cyclosporine
Brand name: Gengraf, Neoral, Sandimmune, Sandimmune
Synonyms: Cyclosporine (oral/injection), CycloSPORINE (Systemic)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cyclosporine Injection-Nexesta Fe
- Cyclosporine Injection-Nexiclon XR
- Cyclosporine Injection-Nexiclon XR Suspension
- Cyclosporine Injection-Nexium
- Cyclosporine Injection-Nexium (Esomeprazole Delayed-Release Capsules)
- Cyclosporine Injection-Nexium (Esomeprazole Powder for Suspension)
- Nexavar-Cyclosporine Oral Solution
- Nexavar-Cyclosporine Oral Solution, Modified
- Nexavar-Cyclosporine Oral, Intravenous
- Nexavar-Cyclosporine oral/injection
- Nexavar-Cyclosporine Soft Gelatin Capsules
- Nexavar-CyFolex