Cyclosporine oral/injection and Donnatal Elixir
Determining the interaction of Cyclosporine oral/injection and Donnatal Elixir and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using PHENobarbital together with cycloSPORINE may decrease the effects of cycloSPORINE. Contact your doctor if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Barbiturates may decrease serum cyclosporine concentrations and efficacy. The mechanism is enhanced hepatic microsomal metabolism of cyclosporine. A case report has described this interaction for phenobarbital; however, the barbiturates are known enzyme inducers. Effects may not be apparent until 1 to 2 weeks after the barbiturate is added to the regimen or its dose is changed.
MANAGEMENT: Cyclosporine levels should be closely monitored during concomitant therapy and more frequently when a barbiturate is started or stopped. The dosage of cyclosporine should be adjusted to maintain therapeutic concentrations. Some experts suggest that this interaction could persist for a week or more following discontinuation of the barbiturate. Alternatively, a benzodiazepine may be used, if clinically appropriate.
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- Cerner Multum, Inc. "Australian Product Information." O 0
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- Noguchi M, Kiuchi C, Akiyama H, et al "Interaction between cyclosporin A and anticonvulsants." Bone Marrow Transplant 9 (1992): 391
- Kerr LE "Drug interactions with cyclosporine." Clin Pharm 3 (1984): 346,348
- "Product Information. Neoral Soft Gelatin Capsules (cyclosporine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
- "Product Information. Sandimmune (cyclosporine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cockburn IT, Krupp P "An appraisal of drug interactions with sandimmun." Transplant Proc 21 (1989): 3845-50
Generic Name: cyclosporine
Brand name: Gengraf, Neoral, Sandimmune, Sandimmune
Synonyms: Cyclosporine (oral/injection), CycloSPORINE (Systemic)
Generic Name: atropine / hyoscyamine / phenobarbital / scopolamine
Brand name: Donnatal, D-Tal, Phenohytro, Chardonna-2, Hyosophen, Donnapine, Elixiral, Bellatal, Spasmolin, Haponal, Antispas, Barbidonna, Donnatal Extentabs, Antispasmodic, Bellalphen, Donnaphen, Spasquid, Alkabel-SR, Bellatal ER, Servira, PB-Hyos, Quadrapax, Phenobarbital with Belladonna Alkaloids
Synonyms: Donnatal
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cyclosporine oral/injection-Donnatal Tablets
- Cyclosporine oral/injection-Donor Prep Kit
- Cyclosporine oral/injection-Dopamine
- Cyclosporine oral/injection-Dopamine and Dextrose
- Cyclosporine oral/injection-Dopamine Hydrochloride
- Cyclosporine oral/injection-Dopamine injection
- Donnatal Elixir-Cyclosporine Soft Gelatin Capsules
- Donnatal Elixir-CyFolex
- Donnatal Elixir-Cyklokapron
- Donnatal Elixir-Cylate
- Donnatal Elixir-Cylert
- Donnatal Elixir-Cyltezo Subcutaneous