Cyclosporine Oral, Intravenous and Fluconazole Intravenous
Determining the interaction of Cyclosporine Oral, Intravenous and Fluconazole Intravenous and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using cycloSPORINE together with fluconazole may increase the effects of cycloSPORINE. Contact your doctor if you experience nausea, vomiting, diarrhea, abdominal pain, fatigue, or headache. If your doctor prescribes these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Fluconazole may inhibit the CYP450 3A4 hepatic and/or gut wall metabolism of cyclosporine. Serum cyclosporine concentrations and risk of toxicity may be increased, although the data are conflicting. This interaction may be more likely with higher doses of fluconazole (more than 200 mg per day).
MANAGEMENT: If concomitant therapy is necessary, serum cyclosporine levels and renal function should be closely monitored. Dosage adjustments may be required. Patients should be advised to notify their physician if they experience nausea, vomiting, diarrhea, abdominal pain, fatigue, or headache.
- Kruger HU, Schuler U, Zimmerman R, Ehninger G "Absence of significant interaction of fluconazole with cyclosporin." J Antimicrob Chemother 24 (1989): 781-6
- Osowski CL, Dix SP, Lin LS, Mullins RE, Geller RB, Wingard JR "Evaluation of the drug interaction between intravenous high-dose fluconazole and cyclosporine or tacrolimus in bone marrow transplant patients." Transplantation 61 (1996): 1268-72
- Back D, Tjia J "Comparative effects of the antimycotic drugs ketoconazole, fluconazole, itraconazole and terbinafine on the metabolism of cyclosporin by human liver microsomes." Br J Clin Pharmacol 32 (1991): 624-6
- Sugar AM, Saunders C, Idelson BA, Bernard DB "Interaction of fluconazole and cyclosporine." Ann Intern Med 110 (1989): 844
- Canafax DM, Graves NM, Hilligoss DM, Carleton BC, Gardner MJ, Matas AJ "Increased cyclosporine levels as a result of simultaneous fluconazole and cyclosporine therapy in renal transplant recipients: a double-blind, randomized pharmacokinetic and safety study." Transplant Proc 23 (1991): 1041-2
- Lopez-Gil JA "Fluconazole-cyclosporin interaction: a dose-dependent effect?" Ann Pharmacother 27 (1993): 427-30
- Torregrosa V, De la Torre M, Campistol JM, et al "Interaction of fluconazole with ciclosporin A." Nephron 60 (1992): 125-6
- Ehninger G, Jaschonek K, Schuler U, Kruger HU "Interaction of fluconazole with cyclosporin." Lancet 2 (1989): 104-5
- Canafax DM, Graves NM, Hilligoss DM, et al "Interaction between cyclosporine and fluconazole in renal allograft recipients." Transplantation 51 (1991): 1014-8
- "Product Information. Sandimmune (cyclosporine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
Generic Name: cyclosporine
Brand name: Gengraf, Neoral, Sandimmune, Sandimmune
Synonyms: Cyclosporine (oral/injection), CycloSPORINE (Systemic)
Generic Name: fluconazole
Brand name: Diflucan
Synonyms: Fluconazole
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cyclosporine Oral, Intravenous-Fluconazole Oral Suspension
- Cyclosporine Oral, Intravenous-Fluconazole Tablets
- Cyclosporine Oral, Intravenous-Flucytosine
- Cyclosporine Oral, Intravenous-Fludara
- Cyclosporine Oral, Intravenous-Fludara injection
- Cyclosporine Oral, Intravenous-Fludarabine
- Fluconazole Intravenous-Cyclosporine oral/injection
- Fluconazole Intravenous-Cyclosporine Soft Gelatin Capsules
- Fluconazole Intravenous-CyFolex
- Fluconazole Intravenous-Cyklokapron
- Fluconazole Intravenous-Cylate
- Fluconazole Intravenous-Cylert