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Cyclosporine Oral Solution and Reglan (Metoclopramide Injection Solution)

Determining the interaction of Cyclosporine Oral Solution and Reglan (Metoclopramide Injection Solution) and the possibility of their joint administration.

Check result:

Cyclosporine Oral Solution <> Reglan (Metoclopramide Injection Solution)

Relevance: 18.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using cycloSPORINE together with metoclopramide may increase the effects of cycloSPORINE. Contact your doctor if you experience nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, or headache. If your doctor prescribes these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Concomitant administration of single-dose cyclosporine and metoclopramide increases cyclosporine bioavailability. Although the exact mechanism is not well understood, metoclopramide-induced increase in gastric emptying may interfere with gastrointestinal degradation of cyclosporine. Serum cyclosporine concentrations and risk of toxicity may be increased.

MANAGEMENT: Cyclosporine levels and renal function, including serum creatinine, should be carefully monitored, during concurrent therapy. Cyclosporine dosage should be adjusted as needed. Patients should be advised to notify their physician if they experience nausea, vomiting, diarrhea, abdominal pain, dizziness, fatigue, or headache.

References

Morse GD, Holdsworth MT, Venuto RC, Gerbasi J, Walshe JJ "Pharmacokinetics and clinical tolerance of intravenous and oral cyclosporine in the immediate postoperative period." Clin Pharmacol Ther 44 (1988): 654-64
Greiff JMC, Rowbotham D "Pharmacokinetic drug interactions with gastrointestinal motility modifying agents." Clin Pharmacokinet 27 (1994): 447-61
Yee GC, McGuire TR "Pharmacokinetic drug interactions with cyclosporin (part II)." Clin Pharmacokinet 19 (1990): 400-15
"Product Information. Sandimmune (cyclosporine)." Sandoz Pharmaceuticals Corporation, East Hanover, NJ.
Wadhwa NK, Schroeder TJ, O'Flaherty E, Pesce AJ, Myre SA, First MR "The effect of oral metoclopramide on the absorption of cyclosporine." Transplantation 43 (1987): 211-3

Cyclosporine Oral Solution

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Cyclosporine (oral/injection), CycloSPORINE (Systemic)

What is Cyclosporine Oral Solution?

Reglan (Metoclopramide Injection Solution)

Generic Name: metoclopramide

Brand name: Reglan, Metozolv ODT

Synonyms: Reglan

What is Reglan (Metoclopramide Injection Solution)?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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