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Cyklokapron and Zovia 1/35

Determining the interaction of Cyklokapron and Zovia 1/35 and the possibility of their joint administration.

Check result:
Cyklokapron <> Zovia 1/35
Relevance: 01.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using tranexamic acid together with ethinyl estradiol is not recommended. Combining these medications may increase the risk of blood clots, which can lead to serious conditions such as stroke, heart attack, heart failure, collapse, and kidney failure. You should seek immediate medical attention if you experience potential signs and symptoms of blood clots such as chest pain; shortness of breath; coughing up blood; blood in the urine; sudden loss of vision; and pain, redness, or swelling in your arm or leg. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

CONTRAINDICATED: There are no clinical data on the use of tranexamic acid in combination with hormonal contraceptives. Because tranexamic acid is an antifibrinolytic agent, concomitant use may further exacerbate the risk of thrombotic events, including venous thromboembolism as well as arterial thromboses such as stroke and myocardial infarction, associated with hormonal contraceptives. The risk is of particular concern in women who are obese or cigarette smokers, especially smokers over the age of 35. Women using hormonal contraception were generally excluded from clinical trials supporting the safety and efficacy of tranexamic acid for the treatment of menorrhagia (heavy menstrual bleeding). However, there have been postmarketing reports of venous and arterial thrombotic events in women who have used tranexamic acid during treatment with combination hormonal contraceptives.

MANAGEMENT: Due to the potential for increased risk of thrombosis in women receiving hormonal contraceptives, the use of tranexamic acid for the treatment of menorrhagia in this population is considered contraindicated. Patients receiving hormonal contraceptives should be advised to seek medical attention immediately if they experience potential signs and symptoms of blood clots such as chest pain, shortness of breath, hemoptysis, hematuria, sudden loss of vision, and pain, redness or swelling in an extremity.

References
  • van Hylckama Vlieg A, Helmerhorst FM, Vandenbroucke JP, Doggen CJ, Rosendaal FR "The venous thrombotic risk of oral contraceptives, effects of oestrogen dose and progestogen type: results of the MEGA case-control study." BMJ 339 (2009): b2921
  • "Product Information. LYSTEDA (tranexamic acid)." Xanodyne Pharmaceuticals Inc, Newport, KY.
  • "Product Information. Cyklokapron (tranexamic acid)." Pharmacia and Upjohn, Kalamazoo, MI.
  • Lidegaard O, Lokkegaard E, Svendsen AL, Agger C "Hormonal contraception and risk of venous thromboembolism: national follow-up study." BMJ 339 (2009): b2890
  • Gomes MP, Deitcher SR "Risk of venous thromboembolic disease associated with hormonal contraceptives and hormone replacement therapy: a clinical review." Arch Intern Med 164 (2004): 1965-76
  • Rosendaal FR, Van Hylckama Vlieg A, Tanis BC, Helmerhorst FM "Estrogens, progestogens and thrombosis." J Thromb Haemost 1 (2003): 1371-80
Cyklokapron

Generic Name: tranexamic acid

Brand name: Cyklokapron, Lysteda

Synonyms: n.a.

Zovia 1/35

Generic Name: ethinyl estradiol / ethynodiol

Brand name: Kelnor, Zovia 1/35, Zovia 1/50, Demulen 1/35, Demulen 1/50, Zovia 1/35e, Kelnor 1/50, Kelnor 1/35, Zovia 1/50e

Synonyms: Zovia 1/35E

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle
Disease interaction