Cymbalta and Topcare Complete Acid Reducer plus Antacid
Determining the interaction of Cymbalta and Topcare Complete Acid Reducer plus Antacid and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Oral antacids and some aluminum, calcium, and magnesium salts may decrease oral H2 blocker plasma concentrations. The mechanism may be related to reduced gastric absorption and bioavailability due to acid-neutralizing effects. Data vary and the clinical significance has not been clearly established. It is recommended that H2 blocker be administered one to two hours before one of these preparations.
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- Covington TR, Lawson LC, Young LL, eds. "Handbook of Nonprescription Drugs. 10th ed." Washington, DC: American Pharmaceutical Association (1993):
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- Mihaly GW, Marino AT, Webster LK, Jones DB, Louis WJ, Smallwood RA "High dose of antacid (Mylanta II) reduces bioavailability of ranitidine." Br Med J 285 (1982): 998-9
- Barzaghi N, Gatti G, Crema F, Perucca E "Impaired bioavailability of famotidine given concurrently with a potent antacid." J Clin Pharmacol 29 (1989): 670-2
- Russell WL, Lopez LM, Normann SA, et al "Effect of antacids on predicted steady-state cimetidine concentrations." Dig Dis Sci 29 (1984): 385-9
- Albin H, Vincon G, Demotes-Mainard F, et al "Effect of aluminium phosphate on the bioavailability of cimetidine and prednisolone." Eur J Clin Pharmacol 26 (1984): 271-3
Generic Name: duloxetine
Brand name: Cymbalta, Irenka, Drizalma Sprinkle
Synonyms: n.a.
Generic Name: calcium carbonate / famotidine / magnesium hydroxide
Brand name: Dual Action Complete, Duo Fusion, Pepcid Complete
Synonyms: Care One Acid Reducer Plus Antacid
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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