Cyproheptadine Hydrochloride and Ipilimumab Intravenous

• Generic Name: cyproheptadine
• Dosage Forms: n.a.
• Other Brand Names:

  Periactin

Treatment of cold urticaria.

Symptomatic relief of perennial (nonseasonal) and seasonal (e.g., hay fever) allergic rhinitis.

Management of nonallergic (vasomotor) rhinitis.

Management of allergic conjunctivitis caused by foods or inhaled allergens.

Management of mild, uncomplicated allergic skin manifestations of urticaria and angioedema.

Treatment of dermatographism.

Amelioration of allergic reactions to blood or plasma.

Adjunct to epinephrine and other standard measures for management of anaphylactic reactions after acute manifestations have been controlled.

Has been effective in some patients for the treatment of Cushing’s syndrome secondary to pituitary disorders; however, in most patients, other therapy (e.g., surgery, radiation therapy) is preferred.

Has been effective for the management of inhibited male or female orgasm (anorgasmy) induced by tricyclic antidepressants, MAO inhibitors, fluoxetine, or antipsychotic agents. However, consider the potential for interactions between these drugs and cyproheptadine. (See Interactions.)

Has been shown to stimulate appetite and weight gain in children and adults; however, few indications for clinical use. May be of some value in the treatment of anorexia nervosa; may be more effective in nonbulimic patients than in those who are bulimic.

Reportedly has been effective in some patients for the management of vascular headaches (e.g., migraine). Efficacy for prophylaxis of migraine not established in randomized controlled studies, but some experts consider the drug to be effective based on consensus and clinical experience.

• Generic Name: ipilimumab
• Dosage Forms: n.a.
• Other Brand Names: Yervoy

Ipilimumab injection is used to treat melanoma (a type of skin cancer) that has spread or cannot be removed by surgery. It is a monoclonal antibody that changes the immune system to help control the growth of cancer cells in the skin.

Ipilimumab injection is also used to help prevent melanoma from coming back after surgical removal.

Ipilimumab injection is also used in combination with other medicines (eg, nivolumab) to treat patients with previously untreated kidney cancer that has spread throughout the body.

Ipilimumab injection is also used with nivolumab to treat microsatellite instability high (MSI-H) or mismatch repair deficient (dMMR) colorectal cancer (cancer of the colon or rectum) that has spread. It is given to patients who have received other cancer treatments (eg, fluoropyrimidine, oxaliplatin, irinotecan) but did not work well.

Ipilimumab is to be given only by or under the immediate supervision of your doctor.