Cyproheptadine Solution and Fludarabine Phosphate

• Generic Name: cyproheptadine
• Dosage Forms: oral solution
• Other Brand Names:

  Periactin

Cyproheptadine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Cyproheptadine is used to treat sneezing, runny nose, itching, red or watery eyes, and other symptoms of seasonal allergies (hay fever). Cyproheptadine is also used to treat other conditions such as eczema or skin reactions to insect bites.

Cyproheptadine is sometimes used to treat certain types of headaches, including migraines.

Cyproheptadine may also be used for purposes not listed in this medication guide.

• Generic Name: fludarabine
• Dosage Forms: n.a.
• Other Brand Names: Fludara, Oforta

Treatment of B-cell CLL (B-CLL) in patients refractory to at least one standard alkylating agent-containing regimen (e.g., chlorambucil with or without prednisone) or whose disease has progressed during treatment; considered a drug of choice. Has been designated an orphan drug by FDA for this use.

Used in the management of previously untreated CLL (has been designated an orphan drug by FDA for this use) or in leukemia that was contemporaneously responsive to standard therapy.

Treatment of low-grade, advanced (stage III or IV) adult non-Hodgkin’s lymphoma that failed or relapsed after previous therapy; has been designated an orphan drug by FDA for use in this condition.

Treatment of either acute myeloid (myelogenous, nonlymphocytic) leukemia (AML, ANLL) or acute lymphocytic leukemia (ALL) refractory to conventional therapy or which has relapsed following remission.

Severe toxicity, associated with the relatively high dosages that appear to be necessary for adequate response in these leukemias, may preclude use of the drug as monotherapy for remission induction of these cancers.

Palliative treatment of prolymphocytic leukemia (PLL) or prolymphocytoid chronic lymphocytic leukemia (CLL-Pro) refractory to standard chemotherapy (e.g., chlorambucil and prednisone).

Treatment of hairy cell leukemia (leukemic reticuloendotheliosis); other drugs (e.g., cladribine, pentostatin) considered the initial therapies of choice.

Treatment of refractory macroglobulinemia.

Treatment of mycosis fungoides, a form of cutaneous T-cell lymphoma.