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Cyproheptadine Solution and Metopirone

Determining the interaction of Cyproheptadine Solution and Metopirone and the possibility of their joint administration.

Check result:
Cyproheptadine Solution <> Metopirone
Relevance: 03.11.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using metyraPONE together with cyproheptadine. Using these medications together may cause metyraPONE to be less effective. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: The effect of metyrapone is diminished in patients concurrently receiving cyproheptadine, which may alter ACTH function test results. The mechanism is unknown, but may involve the antiserotonergic effect of cyproheptadine.

MANAGEMENT: Cyproheptadine should be discontinued before a metyrapone test is administered.

References
  • Plonk J, Feldman JM "Modification of adrenal function by the anti-serotonin agent cyproheptadine." J Clin Endocrinol Metab 42 (1975): 291-5
  • Plonk J, Feldman JM "Adrenal function in the carcinoid syndrome: effects of the serotonin antagonist cyproheptadine." Metabolism 24 (1975): 1035-46
Cyproheptadine Solution

Generic Name: cyproheptadine

Brand name: Periactin

Synonyms: Cyproheptadine

Metopirone

Generic Name: metyrapone

Brand name: Metopirone

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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