Cytarabine and Fludarabine injection

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using cytarabine together with fludarabine may alter the effects of both medications. Cytarabine should be given as a relatively short-term infusion (two to four hours) following fludarabine to minimize an interaction. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSING INTERVAL: Cytarabine can impair the metabolism of fludarabine. The mechanism is inhibition of phosphorylation of arabinosyl-2-fluoroadenine. As a result, plasma levels of the active fludarabine triphosphate, F-ara-ATP, are decreased. Also, F-ara-ATP can potentiate deoxycytidine kinase--that is, the phosphorylation of cytarabine. As a result, plasma levels of the active cytarabine triphosphate, ara-CTP, are increased.

MANAGEMENT: It has been suggested that cytarabine be given as a relatively short-term infusion (two to four hours) following fludarabine to minimize metabolic interference with the subsequent fludarabine dose and to maximize ara-CTP synthesis.

Cytarabine

Generic Name: cytarabine

Brand name: Cytosar-U, Tarabine PFS, Cytosar

Synonyms: Cytarabine (Conventional)

What is Cytarabine?

Fludarabine injection

Generic Name: fludarabine

Brand name: Fludara, Oforta

Synonyms: Fludarabine (injection), Fludarabine

What is Fludarabine injection?