Cytarabine (Conventional) and Trexall

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Cytarabine may cause liver and/or nervous system problems, and using it with other medications that can also affect the liver and/or nervous system such as methotrexate may increase that risk. You may need more frequent monitoring by your doctor to safely use both medications. You should avoid or limit the use of alcohol while being treated with these medications. Call your doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. You should also call your doctor if you develop headaches, confusion, numbness, or paralysis as these may be signs and symptoms of nervous system side effects. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration of methotrexate with other agents known to induce hepatotoxicity, such as cytarabine, may potentiate the risk of liver injury. Methotrexate, especially at higher doses or with prolonged treatment, has been associated with hepatotoxicity including acute hepatitis, chronic fibrosis, necrosis, cirrhosis, and liver enzyme elevations. In addition, the use of intravenous cytarabine with intrathecal methotrexate may increase the risk of severe neurological adverse reactions including headaches, paralysis, coma, and stroke like events.

MANAGEMENT: The use of methotrexate with other potentially hepatotoxic agents, such as cytarabine, should be avoided whenever possible. Patients should be advised to seek medical attention if they experience potential signs and symptoms of hepatotoxicity such as fever, rash, itching, anorexia, nausea, vomiting, fatigue, right upper quadrant pain, dark urine, pale stools, and jaundice. Baseline and regular monitoring of hepatic function is recommended. In addition, caution is advised whenever IV cytarabine is administered with intrathecal methotrexate. Patients should be monitored for signs of neurological adverse effects such as headache, mental status changes, numbness, and paralysis.

Cytarabine (Conventional)

Generic Name: cytarabine

Brand name: Cytosar-U, Tarabine PFS, Cytosar

Synonyms: Cytarabine

What is Cytarabine (Conventional)?

Trexall

Generic Name: methotrexate

Brand name: Rheumatrex Dose Pack, Trexall, Xatmep, Otrexup, Rasuvo, Methotrexate Sodium, Preservative Free

Synonyms: n.a.

What is Trexall?