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Cytomel and Elavil

Determining the interaction of Cytomel and Elavil and the possibility of their joint administration.

Check result:

Cytomel <> Elavil

Relevance: 04.11.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using liothyronine together with amitriptyline can alter the effects of both drugs. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you experience toxicity symptoms such as anxiety, agitation, insomnia, shortness of breath, irregular or fast heartbeat, and lightheadedness or dizziness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration of thyroid hormone replacement therapy with tricyclic antidepressants may accelerate the onset or potentiate the action of tricyclic antidepressants, increasing the risk of cardiac arrhythmias and CNS stimulation. The proposed mechanism may be an increased receptor sensitivity to catecholamines. Some clinicians have used this interaction therapeutically. However, individual cases of paroxysmal tachycardia, hypothyroidism, and thyrotoxicosis have also been reported.

MANAGEMENT: Patients receiving concomitant thyroid hormone replacement therapy and tricyclic antidepressant therapy should be closely monitored for cardiac arrhythmias and CNS stimulation. Advise patients to contact their doctor if they experience toxicity symptoms such as: anxiety, agitation, insomnia, shortness of breath, irregular or fast heartbeat, and lightheadedness or dizziness.

References

Goodwin FK, Prange AJ Jr, Post RM, Muscettola G, Lipton MA "Potentiation of antidepressant effects by L-triiodothyronine in tricyclic nonresponders." Am J Psychiatry 139 (1982): 34-8
"Product Information. Triostat (liothyronine)." JHP Pharmaceuticals, Saddle River, NJ.
"Product Information. Synthroid (levothyroxine)." Abbott Pharmaceutical, Abbott Park, IL.
Joffe RT "The use of thyroid supplements to augment antidepressant medication." J Clin Psychiatry 59 Suppl 5 (1998): 26-9; discussion 30-1
"Product Information. Elavil (amitriptyline)." Stuart Pharmaceuticals, Wilmington, DE.
Wilson IC, Prange AJ, McClane TK, Rabon AM, Lipton MA "Thyroid-hormone enhancement of imipramine in nonretarded depressions." N Engl J Med 282 (1970): 1063-7
Swartz CM "Dependency of tricyclic antidepressant efficacy on thyroid hormone potentiation: case studies." J Nerv Ment Dis 170 (1982): 50-2
Posternak M, Novak S, Stern R, et al. "A pilot effectiveness study: placebo-controlled trial of adjunctive L-triiodothyronine (T3) used to accelerate and potentiate the antidepressant response." Int J Neuropsychopharmacol 11 (2008): 15-25
Joffe RT, Singer W, Levitt AJ, MacDonald C "A placebo-controlled comparison of lithium and triiodothyronine augmentation of tricyclic antidepressants in unipolar refractory depression." Arch Gen Psychiatry 50 (1993): 387-93
Cooke RG "T3 augmentation of a tricyclic antidepressant in a patient receiving T4 maintenance therapy." Am J Psychiatry 147 (1990): 255
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0
Altshuler LL, Bauer M, Frye MA, et al. "Does thyroid supplementation accelerate tricyclic antidepressant response? A review and meta-analysis of the literature." Am J Psychiatry 158 (2001): 1617-22
"Product Information. Cytomel (liothyronine)." Monarch Pharmaceuticals Inc, Bristol, TN.
Wheatley D "Potentiation of amitriptyline by thyroid hormone." Arch Gen Psychiatry 26 (1972): 229-33
Prange AJ, Wilson IC, Rabon AM, Lipton MA "Enhancement of imipramine antidepressant activity by thyroid hormone." Am J Psychiatry 126 (1969): 457-69
Schwarcz G, Halaris A, Baxter L, Escobar J, Thompson M, Young M "Normal thyroid function in desipramine nonresponders converted to responders by the addition of L-triiodothyronine." Am J Psychiatry 141 (1984): 1614-6
"Product Information. Anafranil (clomipramine)." Basel Pharmaceuticals, Summit, NJ.
Extein IL, Gold MS "Thyroid hormone potentiation of tricyclics." Psychosomatics 29 (1988): 166-74
Cooke RG, Joffe RT, Levitt AJ "T3 augmentation of antidepressant treatment in T4-replaced thyroid patients." J Clin Psychiatry 53 (1992): 16-8

Cytomel

Generic Name: liothyronine

Brand name: Cytomel, Triostat

Synonyms: n.a.

What is Cytomel?

Elavil

Generic Name: amitriptyline

Brand name: Elavil, Vanatrip, Endep

Synonyms: n.a.

What is Elavil?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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