Cytomel and Patiromer Sorbitex Calcium

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this interaction is not currently available.ADJUST DOSING INTERVAL: Ion-exchange resins may bind to and decrease the gastrointestinal absorption of thyroid hormones. In one case report, a woman who had undergone a complete thyroidectomy and was receiving levothyroxine 150 mcg/day developed lethargy, hoarseness, and weight gain six months after initiation of sodium polystyrene sulfonate for chronic hyperkalemia secondary to renal failure. The symptoms resolved within six weeks after increasing the levothyroxine dosage to 200 mcg/day and separating the times of administration of the two medications by 10 hours. In an in vitro study, levothyroxine concentrations were reduced by 93% to 98% in the presence of sodium polystyrene sulfonate. MANAGEMENT: Thyroid hormone preparations and ion-exchange resins should be administered at least 4 hours apart. Close clinical and laboratory monitoring of thyroid function is recommended during coadministration, since adjusting the dosing interval may not completely prevent the interaction. References McLean M, Kirkwood I, Epstein M, Jones B, Hall C "Cation-exchange resin and inhibition of intestinal absorption of thyroxine." Lancet 34 (1993): 1286 "Product Information. Kayexalate (sodium polystyrene sulfonate)." Sanofi Winthrop Pharmaceuticals, New York, NY. "Product Information. Synthroid (levothyroxine)." Abbott Pharmaceutical, Abbott Park, IL.

ADJUST DOSING INTERVAL: Ion-exchange resins may bind to and decrease the gastrointestinal absorption of thyroid hormones. In one case report, a woman who had undergone a complete thyroidectomy and was receiving levothyroxine 150 mcg/day developed lethargy, hoarseness, and weight gain six months after initiation of sodium polystyrene sulfonate for chronic hyperkalemia secondary to renal failure. The symptoms resolved within six weeks after increasing the levothyroxine dosage to 200 mcg/day and separating the times of administration of the two medications by 10 hours. In an in vitro study, levothyroxine concentrations were reduced by 93% to 98% in the presence of sodium polystyrene sulfonate.

MANAGEMENT: Thyroid hormone preparations and ion-exchange resins should be administered at least 4 hours apart. Close clinical and laboratory monitoring of thyroid function is recommended during coadministration, since adjusting the dosing interval may not completely prevent the interaction.

Cytomel

Generic Name: liothyronine

Brand name: Cytomel, Triostat

Synonyms: n.a.

What is Cytomel?

Patiromer Sorbitex Calcium

Generic Name: patiromer

Brand name: Veltassa

Synonyms: Patiromer

What is Patiromer Sorbitex Calcium?