Cytomel and Sucroferric oxyhydroxide

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Sucroferric oxyhydroxide may interfere with the absorption of oral thyroid hormone products and reduce their effectiveness. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with sucroferric oxyhydroxide may reduce the oral bioavailability of levothyroxine. The proposed mechanism involves nonspecific adsorption of levothyroxine to the ferric ion component of sucroferric oxyhydroxide, resulting in an insoluble complex that is poorly absorbed from the gastrointestinal tract. According to the product labeling for sucroferric oxyhydroxide, an in vitro interaction with levothyroxine was observed when studied in aqueous solutions that mimic the physico-chemical conditions of the gastrointestinal tract. This is consistent with previous studies that have reported a clinically significant interaction between levothyroxine and iron salts. In one study, 14 patients with hypothyroidism who were taking a stable long-term regimen of levothyroxine demonstrated an increase in mean serum thyrotropin (thyroid-stimulating hormone, or TSH) level from 1.6 to 5.4 mU/L following the addition of ferrous sulfate (300 mg administered simultaneously with levothyroxine 30 to 60 minutes before breakfast) for 3 months. A total of 11 patients had increases in serum TSH at week 12 compared to baseline, including two that had levels above the upper limit of normal for the assay, indicating the presence of hypothyroidism. Nine of the eleven also had an increase in signs and symptoms of hypothyroidism based on subjective evaluation using a clinical score. It is not known whether this interaction occurs with other thyroid hormone preparations.

MANAGEMENT: Oral formulations of levothyroxine should not be prescribed with sucroferric oxyhydroxide.

Cytomel

Generic Name: liothyronine

Brand name: Cytomel, Triostat

Synonyms: n.a.

What is Cytomel?

Sucroferric oxyhydroxide

Generic Name: sucroferric oxyhydroxide

Brand name: Velphoro

Synonyms: Sucroferric Oxyhydroxide

What is Sucroferric oxyhydroxide?