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Cytomel and Warfarin

Determining the interaction of Cytomel and Warfarin and the possibility of their joint administration.

Check result:

Cytomel <> Warfarin

Relevance: 04.11.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

If you are currently being treated with warfarin, you should let your doctor know before you start taking liothyronine. Increasing your thyroid hormone levels can sensitize you to the effects of warfarin, which may increase your risk of bleeding. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. On the other hand, no special precautions are necessary if you have been stable on liothyronine therapy and are now starting treatment with warfarin. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Since thyroid hormones may increase the catabolism of vitamin K-dependent clotting factors, the hypoprothrombinemic response to oral anticoagulants may be enhanced during the initiation of thyroid hormone therapy. No significant effects are expected when warfarin is added to a patient stabilized on thyroid replacement therapy.

MANAGEMENT: INR or prothrombin time should be monitored closely when initiating, discontinuing, or changing the dosage of thyroid hormone therapy in patients stabilized on their oral anticoagulant regimen. Patients should be advised to notify their physician if they develop signs and symptoms of excessive anticoagulation, such as unusual or prolonged bleeding, bruising, vomiting, change in stool or urine color, headache, dizziness, or weakness.

References

Vagenakis AG, Cote R, Miller ME, et al "Enhancement of warfarin-induced hypoprothrombinemia by thyrotoxicosis." Johns Hopkins Med J 131 (1972): 69-73
Rice AJ, McIntosh TJ, Fouts JR, et al "Decrease sensitivity to warfarin in patients with myxedema." Am J Med Sci 262 (1971): 211-5
"Product Information. Synthroid (levothyroxine)." Abbott Pharmaceutical, Abbott Park, IL.
van Oosterom AT, Mattie H, Hermens WT, Veltkamp JJ "The influence of the thyroid function on the metabolic rate of prothrombin, factor VII, and factor X in the rat." Thromb Haemost 35 (1976): 607-19
Walters MB "The relationship between thyroid function and anticoagulant therapy." Am J Cardiol 11 (1963): 112-4
Costigan DC, Freedman MH, Ehrlich RM "Potentiation of oral anticoagulant effect by l-thyroxine." Clin Pediatr (Phila) 23 (1984): 172-4

Cytomel

Generic Name: liothyronine

Brand name: Cytomel, Triostat

Synonyms: n.a.

What is Cytomel?

Warfarin

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Warfarin?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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