Cytoxan (Cyclophosphamide Tablets) and Indocin SR

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

A single case report suggests that the combination of cyclophosphamide and indomethacin may cause serious hyponatremia. It is well known that cyclophosphamide alone can cause hyponatremia by causing a renal tubular concentrating defect, as well as a syndrome that resembles the syndrome of inappropriate antidiuretic hormone secretion (SIADH). Indomethacin may contribute to acute water intoxication by inhibiting synthesis of prostaglandins (which are important in maintaining water and electrolyte homeostasis and renal blood flow). However, it is not known whether indomethacin or other nonsteroidal anti-inflammatory drugs (NSAIDs) potentiate any side effects from cyclophosphamide. More data are needed.

Cytoxan (Cyclophosphamide Tablets)

Generic Name: cyclophosphamide

Brand name: Cytoxan, Neosar, Cytoxan Lyophilized

Synonyms: Cytoxan (Injection), Cytoxan

What is Cytoxan (Cyclophosphamide Tablets)?

Indocin SR

Generic Name: indomethacin

Brand name: Indocin, Indocin SR, Tivorbex

Synonyms: n.a.

What is Indocin SR?