Cytoxan (Cyclophosphamide Tablets) and Sandimmune (Cyclosporine Soft Gelatin Capsules)
Determining the interaction of Cytoxan (Cyclophosphamide Tablets) and Sandimmune (Cyclosporine Soft Gelatin Capsules) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using cycloSPORINE together with cyclophosphamide may decrease the effects of cycloSPORINE. Contact your doctor if your condition changes. If your doctor prescribes these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration of cyclophosphamide with cyclosporine may significantly reduce the serum concentrations and therapeutic effects of cyclosporine. The mechanism of this interaction has not been delineated. Patients receiving this combination are at an increased risk of graft-versus-host disease.
MANAGEMENT: Caution and close clinical and laboratory monitoring are recommended in patients receiving cyclosporine with cyclophosphamide.
- "Product Information. Cytoxan (cyclophosphamide)." Bristol-Myers Squibb, Princeton, NJ.
- Nagamura F, Takahashi T, Takeuchi M, et al. "Effect of cyclophosphamide on serum cyclosporine levels at the conditioning of hematopoietic stem cell transplantation." Bone Marrow Transplant 32 (2003): 1051-8
- Cerner Multum, Inc. "Australian Product Information." O 0
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: cyclophosphamide
Brand name: Cytoxan, Neosar, Cytoxan Lyophilized
Synonyms: Cytoxan (Injection), Cytoxan
Generic Name: cyclosporine
Brand name: Sandimmune, Gengraf, Neoral, Sandimmune
Synonyms: Sandimmune (Injection), Sandimmune
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Cytoxan (Cyclophosphamide Tablets)-Sandimmune Oral
- Cytoxan (Cyclophosphamide Tablets)-Sandostatin
- Cytoxan (Cyclophosphamide Tablets)-Sandostatin LAR
- Cytoxan (Cyclophosphamide Tablets)-Sandostatin LAR Depot
- Cytoxan (Cyclophosphamide Tablets)-Sandostatin LAR Depot injection
- Cytoxan (Cyclophosphamide Tablets)-Sani-Supp
- Sandimmune (Cyclosporine Soft Gelatin Capsules)-Cytoxan Lyophilized
- Sandimmune (Cyclosporine Soft Gelatin Capsules)-Cytra K Oral Solution
- Sandimmune (Cyclosporine Soft Gelatin Capsules)-Cytra-2
- Sandimmune (Cyclosporine Soft Gelatin Capsules)-Cytra-2 Oral Solution
- Sandimmune (Cyclosporine Soft Gelatin Capsules)-Cytra-3
- Sandimmune (Cyclosporine Soft Gelatin Capsules)-Cytra-3 Oral Syrup