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Cytoxan Lyophilized and Gengraf Capsules

Determining the interaction of Cytoxan Lyophilized and Gengraf Capsules and the possibility of their joint administration.

Check result:

Cytoxan Lyophilized <> Gengraf Capsules

Relevance: 26.02.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using cycloSPORINE together with cyclophosphamide may decrease the effects of cycloSPORINE. Contact your doctor if your condition changes. If your doctor prescribes these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration of cyclophosphamide with cyclosporine may significantly reduce the serum concentrations and therapeutic effects of cyclosporine. The mechanism of this interaction has not been delineated. Patients receiving this combination are at an increased risk of graft-versus-host disease.

MANAGEMENT: Caution and close clinical and laboratory monitoring are recommended in patients receiving cyclosporine with cyclophosphamide.

References

"Product Information. Cytoxan (cyclophosphamide)." Bristol-Myers Squibb, Princeton, NJ.
Nagamura F, Takahashi T, Takeuchi M, et al. "Effect of cyclophosphamide on serum cyclosporine levels at the conditioning of hematopoietic stem cell transplantation." Bone Marrow Transplant 32 (2003): 1051-8
Cerner Multum, Inc. "Australian Product Information." O 0
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Cytoxan Lyophilized

Generic Name: cyclophosphamide

Brand name: Cytoxan, Neosar, Cytoxan Lyophilized

Synonyms: n.a.

What is Cytoxan Lyophilized?

Gengraf Capsules

Generic Name: cyclosporine

Brand name: Gengraf, Neoral, Sandimmune, Sandimmune

Synonyms: Gengraf (Capsules, Modified), Gengraf

What is Gengraf Capsules?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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