Cytoxan Lyophilized and Jantoven

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using warfarin together with cyclophosphamide may alter the effects of warfarin. Call your doctor promptly if you have any signs of blood clots such as chest pain, shortness of breath, sudden loss of vision, or pain, redness or swelling in an extremity. Using these medications together may also cause you to bleed more easily. Contact your doctor if you experience any unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness. You may need a dose adjustment in addition to testing of your prothrombin time or International Normalized Ratio (INR). It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without talking to your doctor first.

MONITOR: Cyclophosphamide may increase or decrease the anticoagulant activity of warfarin by an unknown mechanism. Since, in some cases, the anticoagulant effect of warfarin has markedly increased after cyclophosphamide has been discontinued, some experts have speculated that cyclophosphamide stimulates the hepatic metabolism of warfarin. According to this suggestion, discontinuing cyclophosphamide could decrease metabolism, increase plasma levels, and increase the anticoagulant effect of warfarin. Other oral anticoagulants may interact with cyclophosphamide in a similar manner.

MANAGEMENT: Careful monitoring of the INR during coadministration and after discontinuation is recommended. Patients should be advised to promptly report any signs of bleeding (e.g., pain, swelling, headache, dizziness, weakness, vaginal bleeding, nosebleeds, bleeding of gums from brushing, unusual bleeding or bruising, red or brown urine, or red or black stools) or blood clots (e.g. chest pain, shortness of breath, sudden loss of vision, or pain, redness or swelling in an extremity).

Cytoxan Lyophilized

Generic Name: cyclophosphamide

Brand name: Cytoxan, Neosar, Cytoxan Lyophilized

Synonyms: n.a.

What is Cytoxan Lyophilized?

Jantoven

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Jantoven?