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Cytoxan Lyophilized and Pentostatin Intravenous

Determining the interaction of Cytoxan Lyophilized and Pentostatin Intravenous and the possibility of their joint administration.

Check result:

Cytoxan Lyophilized <> Pentostatin Intravenous

Relevance: 26.02.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using cyclophosphamide together with pentostatin may increase the risk of side effects that affect your heart function and can lead to serious or life-threatening complications. Contact your doctor if you experience shortness of breath, difficulty breathing, dizziness, fainting, palpitations, or confusion. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration of pentostatin with cyclophosphamide may enhance the cardiotoxic effects of cyclophosphamide. The mechanism of this interaction has not been delineated. Two cases of fatal cardiovascular collapse have been reported following administration of intravenous pentostatin with high-dose oral cyclophosphamide.

MANAGEMENT: Patients receiving pentostatin and cyclophosphamide should be monitored for development of signs and symptoms of cardiotoxicity including, but not limited to respiratory distress, pulmonary edema, hypotension, hypothermia, and confusion. Some authorities recommend avoiding the use of intravenous pentostatin with high-dose oral cyclophosphamide.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0
"Product Information. Cytoxan (cyclophosphamide)." Bristol-Myers Squibb, Princeton, NJ.
"Product Information. Nipent (pentostatin)." Hospira Inc, Lake Forest, IL.

Cytoxan Lyophilized

Generic Name: cyclophosphamide

Brand name: Cytoxan, Neosar, Cytoxan Lyophilized

Synonyms: n.a.

What is Cytoxan Lyophilized?

Pentostatin Intravenous

Generic Name: pentostatin

Brand name: Nipent

Synonyms: Pentostatin

What is Pentostatin Intravenous?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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