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D-Care 100X and Procainamide injection

Determining the interaction of D-Care 100X and Procainamide injection and the possibility of their joint administration.

Check result:
D-Care 100X <> Procainamide injection
Relevance: 08.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using lidocaine together with procainamide can affect the rhythm of your heart and cause mental status changes. Contact your doctor if you experience tiredness, dizziness, fainting, confusion, restlessness, hallucinations. Tremor, difficulty breathing, and an irregular heartbeat. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Limited data suggest that the combination of lidocaine and procainamide may result in an increased risk of conduction abnormalities, including complete AV heart block, and increased risk of nervous system side effects such as restlessness and hallucinations. Patients with preexisting conduction abnormalities are at higher risk for conduction abnormalities with the combination.

MANAGEMENT: Close monitoring of the patient's hemodynamics, ECG, and mental status is recommended, especially in high-risk patients.

References
  • Ilyas M, Owens D, Kvasnicka G "Delirium induced by a combination of anti-arrhythmic drugs." Lancet 2 (1969): 1368-9
  • Cote P, Harrison DC, Basile J, Schroder JS "Hemodynamic interaction of procainamide and lidocaine after experimental myocardial infarction." Am J Cardiol 32 (1973): 937-42
D-Care 100X

Generic Name: epinephrine / lidocaine

Brand name: D-Care 100X, Lignospan Forte, Lignospan Standard, Xylocaine MPF With Epinephrine, Xylocaine With Epinephrine

Synonyms: Lidocaine and Epinephrine

Procainamide injection

Generic Name: procainamide

Brand name: Pronestyl, Procan SR, Pronestyl-SR, Procanbid

Synonyms: Procainamide (injection), Procainamide

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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