Dabigatran Etexilate and Sodium Picosulfate, Magnesium Oxide, and Citric Acid Solution
Determining the interaction of Dabigatran Etexilate and Sodium Picosulfate, Magnesium Oxide, and Citric Acid Solution and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Taking the dabigatran and magnesium oxide doses too close together may interfere with the absorption of dabigatran and reduce its effectiveness. To prevent or minimize the interaction, you should take dabigatran at least two hours before magnesium oxide. In addition, you should avoid taking magnesium oxide within 24 hours after orthopedic surgery. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: Coadministration with an antacid may reduce the bioavailability of dabigatran following oral administration of dabigatran etexilate. The mechanism of interaction has not been described. In population pharmacokinetic analyses, a reduction in dabigatran exposure by 35% was seen over the first 24 hours following surgery. Thereafter, a reduction of about 11% was observed.
MANAGEMENT: Dabigatran should be administered at least two hours before taking an antacid. Coadministration with dabigatran should be avoided within 24 hours after orthopedic surgery.
- "Product Information. Pradax (dabigatran)." Boehringer Ingelheim (Canada) Ltd, Burlington, IA.
Generic Name: dabigatran
Brand name: Pradaxa
Synonyms: Dabigatran
Generic Name: citric acid / magnesium oxide / sodium picosulfate
Brand name: Clenpiq, Prepopik
Synonyms: Citric acid, magnesium oxide, and sodium picosulfate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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