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Dabrafenib and Neut

Determining the interaction of Dabrafenib and Neut and the possibility of their joint administration.

Check result:

Dabrafenib <> Neut

Relevance: 17.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Talk to your doctor before using dabrafenib together with sodium bicarbonate. By reducing stomach acid, there is a possibility that sodium bicarbonate and other medications like it may decrease the absorption of dabrafenib and make it less effective. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Drugs that alter the pH of the upper gastrointestinal tract may affect the solubility of dabrafenib and reduce its bioavailability. The interaction has not been formally studied with H2-receptor antagonists or antacids; however, the solubility of dabrafenib is known to be pH-dependent. It has been reported to be very slightly soluble at pH 1 and practically insoluble above pH 4 in aqueous media.

MANAGEMENT: Until more information is available, caution is advised if dabrafenib is used in combination with H2-receptor antagonists or antacids. The potential for diminished therapeutic effects of dabrafenib should be considered, and pharmacologic response should be closely monitored.

References

"Product Information. Prevacid (lansoprazole)." TAP Pharmaceuticals Inc, Deerfield, IL.
"Product Information. Tafinlar (dabrafenib)." GlaxoSmithKline, Research Triangle Park, NC.
"Product Information. Zantac (ranitidine)." Glaxo Wellcome, Research Triangle Park, NC.
"Product Information. Aciphex (rabeprazole)" Janssen Pharmaceuticals, Titusville, NJ.
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0
"Product Information. Dexilant (dexlansoprazole)." Takeda Pharmaceuticals America, Lincolnshire, IL.

Dabrafenib

Generic Name: dabrafenib

Brand name: Tafinlar

Synonyms: n.a.

What is Dabrafenib?

Neut

Generic Name: sodium bicarbonate

Brand name: Neut

Synonyms: Neut Injection

What is Neut?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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