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Dabrafenib Mesylate and Tums

Determining the interaction of Dabrafenib Mesylate and Tums and the possibility of their joint administration.

Check result:

Dabrafenib Mesylate <> Tums

Relevance: 10.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Talk to your doctor before using dabrafenib together with calcium carbonate. By reducing stomach acid, there is a possibility that calcium carbonate and other medications like it may decrease the absorption of dabrafenib and make it less effective. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Drugs that alter the pH of the upper gastrointestinal tract may affect the solubility of dabrafenib and reduce its bioavailability. The interaction has not been formally studied with H2-receptor antagonists or antacids; however, the solubility of dabrafenib is known to be pH-dependent. It has been reported to be very slightly soluble at pH 1 and practically insoluble above pH 4 in aqueous media.

MANAGEMENT: Until more information is available, caution is advised if dabrafenib is used in combination with H2-receptor antagonists or antacids. The potential for diminished therapeutic effects of dabrafenib should be considered, and pharmacologic response should be closely monitored.

References

"Product Information. Prevacid (lansoprazole)." TAP Pharmaceuticals Inc, Deerfield, IL.
"Product Information. Tafinlar (dabrafenib)." GlaxoSmithKline, Research Triangle Park, NC.
"Product Information. Zantac (ranitidine)." Glaxo Wellcome, Research Triangle Park, NC.
"Product Information. Aciphex (rabeprazole)" Janssen Pharmaceuticals, Titusville, NJ.
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0
"Product Information. Dexilant (dexlansoprazole)." Takeda Pharmaceuticals America, Lincolnshire, IL.

Dabrafenib Mesylate

Generic Name: dabrafenib

Brand name: Tafinlar

Synonyms: Dabrafenib

What is Dabrafenib Mesylate?

Tums

Generic Name: calcium carbonate

Brand name: Tums Smoothies, Tums, Cal-Mint, Calci-Chew, Oysco 500, Calci Mix, Os-Cal 500, Oyst Cal 500, Oyster Shell Calcium 500, Nephro Calci, Amitone, Dicarbosil, Equilet, Chooz, Tums E-X, Alkets, Titralac, Oyster Cal 500, Calcitab, Oyster Shell, Oyster Calcium, Super Calcium, Calcium Concentrate, Caltro, Oyster, Oyster Cal, Cal Oys, Alkums, Cal-Gest, Tums 500, Tums Ultra, Alka-Mints, Calcarb, Caltrate, Rolaids Sodium Free, Amilac, Calcium Oyster, Oyst Cal, Calcium Liquid Softgel, Mylanta Child, Maalox Quick Dissolve, Maalox Quick Dissolve Maximum Strength, Ultra Mylanta Calci Tabs, Extra Strength Mylanta Calci Tabs, Os-Cal, Surpass, Surpass Extra Strength, Icar Prenatal Chewable Calcium, Tums Extra Strength, Maalox Quick Dissolve Extra Strength, Calcium Oyster Shell, Maalox Antacid Barrier, Rolaids Soft Chew, Pepto Children's, Maalox Regular Strength, Maalox Children's, Tums Kids, Tums QuikPak, Calci-Mix, Alcalak, Tums Chewy Bites, Tums Chewy Delights, Tums Sugar-Free, Calci Mix, OsCal 500

Synonyms: n.a.

What is Tums?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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